The KDEL Antibody, Clone 1F2: ATTO 390 from MyBioSource.com is a Mouse Monoclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The KDEL Antibody, Clone 1F2: ATTO 390 has been validated for the following applications: Western Blot.
Description
The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). Grp78 and Grp94 and PDI all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER